β-Catenin Signaling Is a Critical Event in ErbB2-Mediated Mammary Tumor Progression
نویسندگان
چکیده
منابع مشابه
Loss of the 14-3-3σ tumor suppressor is a critical event in ErbB2-mediated tumor progression.
UNLABELLED 14-3-3σ is a putative tumor suppressor involved in cell-cycle progression and epithelial polarity. We demonstrate that loss of one or both copies of the conditional 14-3-3σ allele results in accelerated mammary and salivary tumorigenesis in mice expressing an activated erbB2 oncogene under the endogenous erbB2 promoter. Significantly, the majority of tumors bearing a single condition...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2013
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-12-3925